Recombinant production cell lines
The value of recombinant proteins is constantly rising in health management and the development of human therapies. Therefore, a significantly growing demand for therapeutic proteins exists. We are employing and improving host cell lines, expression vectors and selection strategies for clone development and are investigating the influence of growth media and other environmental conditions for process optimization on various recombinant cell lines. With our research, we aim to establish a broader insight into factors influencing the production pathway and we are analyzing incidences in the production cell line induced by the expression of recombinant proteins. For this purpose, we have an abundant cell bank with numerous recombinant and host cell lines including CHO (DUKX, DG44, K1, S), NS0, HEK, Vero, hybridoma etc. The list of developed expression clones includes various subclasses of antibodies (IgG, IgA, IgM, IgE), synthetic antibody constructs (scFv-Fc, Fab), cytokines, hormones and fusion proteins (EpoFc).